Casey and Frannie are both running for the ZBZ presidency, but the sorority ultimately choose Ashleigh as president. Frannie decides to leave ZBZ together with several others and founds a new house, Iota Kappa Iota. Frannie’s beau, Evan, receives millions of dollars from his trust fund, and she is quick to see the potential for funding her new sorority. Casey dates Max, but they struggle to keep the relationship afloat when he graduates and they had to spend the summer apart from each other. We learn that Max has just turned down a full grad school scholarship to stay at Cyprus-Rhodes University with Casey.

Meanwhile, Rusty dates Jordan, the ZBZ pledge, and Cappie and Evan are chosen to be part of a secret society headed by Dean Bowman. This gives the two to reconcile their differences. Casey confronts her feelings for Cappie, who suprises her by telling her that he does not want to mess up Casey’s relationship with Max, and so she dumps him.
| Episode No | Episode Name | Directed by | Air Date |
|---|---|---|---|
| Episode 23 | "Brothers and Sisters" | Michael Lange | 26-Aug-08 |
| Episode 24 | "Crush Landing" | Patrick Norris | 2-Sep-08 |
| Episode 25 | "Let’s Make a Deal" | Linda Mendoza | 9-Sep-08 |
| Episode 26 | "Gays, Ghosts and Gamma Rays" | Michael Lange | 16-Sep-08 |
| Episode 27 | "Pledge Allegiance" | Gil Junger | 23-Sep-08 |
| Episode 28 | "See You Next Time, Sisters" | Michael Lange | 30-Sep-08 |
| Episode 29 | "Formally Yours" | Fred Gerber | 7-Oct-08 |
| Episode 30 | "The Popular Vote" | Melanie Mayron | 14-Oct-08 |
| Episode 31 | "Three’s A Crowd" | Sandy Smolan | 21-Oct-08 |
| Episode 32 | "Hell Week" | Michael Lange | 28-Oct-08 |
| Episode 33 | "Take Me Home, Cyprus-Rhodes" | Michael Lange | 30-Mar-09 |
| Episode 34 | "From Rushing with Love" | Fred Savage | 6-Apr-09 |
| Episode 35 | "Engendered Species" | Michael Lange | 13-Apr-09 |
| Episode 36 | "Big Littles & Jumbo Shrimp" | Shawn Piller | 20-Apr-09 |
| Episode 37 | "Evasive Actions" | Michael Lange | 27-Apr-09 |
| Episode 38 | "Dearly Beloved" | Melanie Mayron | 4-May-09 |
| Episode 39 | "Guilty Treasures" | Norman Buckley | 11-May-09 |
| Episode 40 | "Divine Secrets and the ZBZ Sisterhood" | Michael Lange | 18-May-09 |
| Episode 41 | "Social Studies" | Patrick R. Norris | 25-May-09 |
| Episode 42 | "Isn’t It Bro-mantic" | Michael Lange | 1-Jun-09 |
| Episode 43 | "Tailgate Expectation" | Tim Matheson | 8-Jun-09 |
| Episode 44 | "At World’s End" | Michael Lange | 15-Jun-09 |
